Introduction

Pharmacogenomics aims at understanding how genetic variants influence drug efficacy and toxicity. Many drugs that are currently available are “one size fits all,” but they don't work the same way for everyone owing to the distinction of genes. Consequently, pharmacogenomics is often considered one of the most actionable areas of the personalized medicine paradigm. A pharmacogenomics knowledge graph was constructed for precision medication in this research, which reflected the relationships between drugs, genes, diseases, as well as personalized medication and adverse reaction. Taking melanoma caused by BRAF gene mutation into consideration, we covered seven related drugs in the pharmacogenomics knowledge representation model.

Introduction

Pharmacogenomics aims at understanding how genetic variants influence drug efficacy and toxicity. Many drugs that are currently available are “one size fits all,” but they don't work the same way for everyone owing to the distinction of genes. Consequently, pharmacogenomics is often considered one of the most actionable areas of the personalized medicine paradigm. A pharmacogenomics knowledge graph was constructed for precision medication in this research, which reflected the relationships between drugs, genes, diseases, as well as personalized medication and adverse reaction. Taking melanoma caused by BRAF gene mutation into consideration, we covered seven related drugs in the pharmacogenomics knowledge representation model.